|
Demographics
|
|
Age, mean (SD), year
|
67.7 (15.4)
|
70.3 (15.2)
|
63.9 (15.0)
|
0.040
|
|
Male, No. (%)
|
62 (62.0)
|
33 (56.9)
|
29 (69.0)
|
0.217
|
|
BMI, mean (SD), kg/m2
|
21.7 (4.2)
|
21.6 (4.3)
|
21.7 (4.2)
|
0.877
|
|
Severity of illness on the beginning of septic shock, mean (SD) or median (IQR)
|
|
APACHE-II score
|
23.8 (8.9)
|
25.4 (9.1)
|
21.7 (8.3)
|
0.037
|
|
Vasoactive inotropic score
|
103.5 (20.8–174.5)
|
137.2 (73.4–220.9)
|
27.7 (0.7–102.5)
|
< 0.001
|
|
Vital signs, mean (SD) or median (IQR)
|
|
MAP, mmHg
|
80.1 (13.2)
|
72.9 (9.9)
|
90.0 (10.6)
|
<0.001
|
|
Respiratory rate, times/min
|
26.0 (20.0–34.8)
|
25.0 (20.0–32.0)
|
29.5 (20.8–37.3)
|
0.135
|
|
Heart rate, beats/min
|
117.2 (26.8)
|
117.4 (27.6)
|
117.0 (26.0)
|
0.948
|
|
Body temperature, °C
|
37.0 (36.2–38.0)
|
37.0 (36.3–38.0)
|
37.0 (36.0–38.0)
|
0.916
|
|
Focus of infection, NO. (%)
|
|
Bloodstream infection
|
18 (18.0)
|
9 (15.5)
|
9 (21.4)
|
0.448
|
|
Pulmonary infection
|
37 (37.0)
|
19 (32.8)
|
18 (42.9)
|
0.302
|
|
Abdominal infection
|
23 (23.0)
|
13 (22.4)
|
10 (23.8)
|
0.870
|
|
Urinary infection
|
3 (3.0)
|
3 (5.2)
|
0 (0.0)
|
0.135
|
|
Infection of biliary tract
|
7 (7.0)
|
5 (8.6)
|
2 (4.8)
|
0.455
|
|
Skin soft-tissue infection
|
1 (1.0)
|
1 (1.7)
|
0 (0.0)
|
0.392
|
|
Other
|
11 (11.0)
|
8 (13.8)
|
3 (7.1)
|
0.294
|
|
Medical history, No. (%)
|
|
Chronic heart disease
|
17 (17.0)
|
12 (20.7)
|
5 (11.9)
|
0.248
|
|
Chronic kidney disease
|
10 (10.0)
|
6 (10.3)
|
4 (9.5)
|
0.893
|
|
Diabetics
|
12 (12.0)
|
7 (12.1)
|
5 (11.9)
|
0.980
|
|
Hypertension
|
12 (12.0)
|
6 (10.3)
|
6 (14.3)
|
0.549
|
|
Combined therapy
|
|
Mechanical ventilation, No. (%)
|
95 (95.0)
|
55 (94.8)
|
40 (95.2)
|
0.926
|
|
CRRT, No. (%)
|
59 (59.0)
|
40 (69.0)
|
19 (45.2)
|
0.017
|
|
Day-1 total amount, mean (SD), mla
|
3935.2 (1500.9)
|
4365.6 (1568.3)
|
3340.8 (1181.4)
|
0.001
|
|
Day-1 output, mean (SD), mlb
|
2447.8 (1386.5)
|
2385.6 (1379.9)
|
2533.9 (1407.7)
|
0.600
|
|
Day-1 volume, mean (SD), mlc
|
1487.3 (1831.0)
|
1980.0 (1932.3)
|
806.9 (1444.5)
|
0.001
|
|
Outcomes
|
|
Day-7 mortality, No. (%)
|
34 (34.0)
|
30 (51.7)
|
4 (9.5)
|
<0.001
|
|
Day-14 mortality, No. (%)
|
47 (47.0)
|
39 (67.2)
|
8 (19.0)
|
<0.001
|
|
Day-28 mortality, No. (%)
|
57 (57.0)
|
43 (74.1)
|
14 (33.3)
|
<0.001
|
|
ICU mortality, No. (%)
|
58 (58.0)
|
43 (74.1)
|
15 (35.7)
|
< 0.001
|
|
ICU LOS, median (IQR), d
|
9.0 (5.0–17.8)
|
8.0 (3.0–13.3)
|
12.5 (6.8–20.8)
|
0.018
|
|
Hospital mortality, No. (%)
|
61 (61.0)
|
44 (75.9)
|
17 (40.5)
|
< 0.001
|
|
Hospital LOS, median (IQR), d
|
22.0 (11.0–32.8)
|
15.5 (6.8–28.0)
|
23.5 (15.5–40.3)
|
0.006
|
|
PICCO data, mean (SD) or median (IQR)
|
|
CVP, cmH2O
|
14.7 (5.9)
|
16.0 (6.1)
|
12.9 (5.2)
|
0.009
|
|
GEDI, ml/m2
|
707.0 (605.5–842.3)
|
698.0 (599.3–861)
|
712.0 (616.8–817.5)
|
0.992
|
|
SVRI, dyn.s.cm-5.m2
|
2063.7 (792.6)
|
2119.7 (921.3)
|
1986.5 (571.1)
|
0.376
|
|
ELWI, ml/kg
|
9.0 (6.6–14.5)
|
9.2 (7.0–15.0)
|
8.2 (6.0–13.6)
|
0.206
|
|
CI, L/min/m2
|
3.09 (0.98)
|
2.77 (0.98)
|
3.55 (0.79)
|
<0.001
|
|
CPI, W/m2
|
0.55 (0.20)
|
0.44 (0.16)
|
0.70 (0.16)
|
<0.001
|
|
LVEF, median (IQR), %
| | | | |
|
LVEF
|
60.0 (55.0–64.8)
|
58.7 (54.0–63.3)
|
62.0 (59.4–65.3)
|
0.006
|
|
Laboratory test, mean (SD) or median (IQR)
|
|
White blood cell, ×109/L
|
10.8 (6.1–19.1)
|
12.8 (6.2–21.2)
|
8.7 (5.8–15.6)
|
0.180
|
|
Neutrophils lymphocytes ratio
|
21.8 (26.4)
|
22.7 (27.6)
|
20.6 (24.9)
|
0.702
|
|
Hemoglobin, g/L
|
94.6 (24.4)
|
92.1 (23.8)
|
98.1 (25.0)
|
0.229
|
|
Platelet, ×109/L
|
99.0 (41.0–191.5)
|
72.5 (33.8–186.8)
|
129.5 (54.8–208.3)
|
0.051
|
|
Total bilirubin, μmol/L
|
23.5 (13.0–45.5)
|
35.0 (13.8–55.7)
|
16.7 (11.0–29.3)
|
0.005
|
|
Albumin, g/L
|
25.3 (4.8)
|
24.6 (4.9)
|
26.4 (4.6)
|
0.061
|
|
Serum creatinine, μmol/L
|
156.9 (92.4–229.5)
|
161.2 (95.9–234.7)
|
125.6 (86.6–222.1)
|
0.311
|
|
Urea, mmol/L
|
12.0 (8.0–17.9)
|
11.8 (7.4–19.0)
|
12.2 (8.1–16.0)
|
0.810
|
|
Calcium ion, mmol/L
|
1.98 (1.87–2.17)
|
2.00 (1.89–2.17)
|
1.97 (1.87–2.18)
|
0.722
|
|
D-dimer, mg/L
|
5.3 (3.1–10.0)
|
5.1 (3.2–15.8)
|
6.2 (2.8–8.4)
|
0.603
|
|
Fibrinogen, g/L
|
3.6 (1.8)
|
3.3 (1.7)
|
4.1 (1.8)
|
0.023
|
|
Procalcitonin, ng/ml
|
24.4 (3.0–56.7)
|
31.6 (5.3–58.4)
|
19.0 (1.0–56.4)
|
0.336
|
|
Lactate, mmol/L
|
4.8 (2.0–8.9)
|
5.6 (2.3–12.1)
|
3.8 (1.9–5.6)
|
0.006
|
