Neuromuscular blockade in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials

Table 2 Quality of evidence assessment

Question	Quality assessment				Quality of evidence
Question	Bias	Inconsistency	Indirectness	Imprecision	Quality of evidence
28-day mortality	Serious^a	Moderate^b	No serious indirectness	No serious imprecision	Moderate
90-day mortality	Serious^a	Moderate^b	No serious indirectness	Undetected	Moderate
ICU mortality	Serious^a	Undetected	Undetected	Detected^c	Low
Mechanical ventilation duration	Serious^a	Undetected	No serious indirectness	No serious imprecision	Moderate
Ventilator-free days at day 28th	Serious^a	Undetected	No serious indirectness	No serious imprecision	Moderate
ICU weakness	Serious^a	Undetected	No serious indirectness	No serious imprecision	Moderate
Barotrauma	Serious^a	Undetected	No serious indirectness	No serious imprecision	Moderate

^aBias was rated high because of no blinding in four out of five studies (see Table 1)
^bInconsistency across studies in these two outcomes based on I² was moderate
^cImprecision was detected for this outcome because there was no value for this outcome available for 1 out of 5 studies

ISSN: 2052-0492