Table 3 Summary diagnostic power based on subgroup analyses
From: Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis
| Subgroups | Number of studies | Cases number of sepsis | Cases number of controls | Sen (95% CI) | Spe (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| Population | |||||||||
| Adults | 21 | 1902 | 1283 | 0.80 (0.73–0.85) | 0.88 (0.82–0.92) | 6.4 (4.4–9.4) | 6.4 (4.4–9.4) | 28 (17–46) | 0.91 (0.88–0.93) |
| Children | 8 | 421 | 280 | 0.81 (0.77–0.85) | 0.77 (0.67–0.84) | 3.47 (2.4–5.0) | 0.24 (0.19–0.30) | 14 (8–24) | 0.82 (0.79–0.86) |
| Region | |||||||||
| China | 23 | 2003 | 1368 | 0.80 (0.75–0.84) | 0.85 (0.80–0.89) | 5.4 (4.0–7.1) | 0.24 (0.19–0.30) | 23 (15–33) | 0.89 (0.86–0.92) |
| Non-China | 7 | 334 | 209 | 0.80 (0.67–0.89) | 0.84 (0.69–0.93) | 5.1 (2.4–11.0) | 0.24 (0.13–0.43) | 21 (7–71) | 0.89 (0.86–0.91) |
| Regulation mode | |||||||||
| Upregulated | 20 | 1544 | 1031 | 0.80 (0.74–0.85) | 0.83 (0.78–0.87) | 4.8 (3.5–6.4) | 0.24 (0.18–0.32) | 20 (13–32) | 0.89 (0.86–0.91) |
| Downregulated | 10 | 793 | 546 | 0.80 (0.73–0.85) | 0.89 (0.80–0.94) | 7.3 (4.1–13.1) | 0.23 (0.18–0.29) | 32 (18–56) | 0.89 (0.86–0.91) |
| Specimen | |||||||||
| Serum | 15 | 1231 | 711 | 0.82 (0.76–0.88) | 0.87 (0.79–0.93) | 6.4 (3.9–10.5) | 0.20 (0.15–0.27) | 32 (19–54) | 0.91 (0.88–0.93) |
| Plasm | 13 | 1060 | 822 | 0.77 (0.70–0.82) | 0.84 (0.78–0.88) | 4.7 (3.4–6.6) | 0.28 (0.21–0.37) | 17 (10–29) | 0.88 (0.84–0.90) |
| Diagnostic criteria | |||||||||
| Sepsis-3 | 5 | 406 | 132 | 0.85 (0.69–0.94) | 0.87 (0.69–0.95) | 6.8 (2.8–16.1) | 0.17 (0.08–0.35) | 40 (20–81) | 0.93 (0.90–0.95) |
| Sepsis-1/2 | 23 | 1892 | 1406 | 0.78 (0.73–0.82) | 0.84 (0.79–0.88) | 4.8 (3.7–6.2) | 0.26 (0.22–0.32) | 18 (13–26) | 0.87 (0.84–0.90) |
| Internal reference types | |||||||||
| U6 | 12 | 1109 | 856 | 0.76 (0.68–0.83) | 0.83 (0.77–0.87) | 4.4 (3.3–5.8) | 0.29 (0.21–0.39) | 15 (9–24) | 0.87 (0.84–0.89) |
| Non-U6 | 9 | 436 | 207 | 0.79 (0.70–0.86) | 0.96 (0.82–0.99) | 19.5 (3.9–97.8) | 0.22 (0.15–0.32) | 89 (15–518) | 0.90 (0.87–0.92) |
| Control groups | |||||||||
| SIRS | 14 | 806 | 426 | 0.74 (0.69–0.78) | 0.87 (0.79–0.92) | 5.7 (3.5–9.4) | 0.30 (0.26–0.36) | 19 (11–33) | 0.82 (0.78–0.85) |
| HC | 14 | 1404 | 1076 | 0.83 (0.76–0.88) | 0.82 (0.76–0.87) | 4.6 (3.4–6.1) | 0.21 (0.15–0.30) | 22 (14–35) | 0.89 (0.86–0.91) |
| Sample size | |||||||||
| > 100 | 15 | 1746 | 1181 | 0.81 (0.73–0.87) | 0.83 (0.77–0.87) | 4.7 (3.6–6.2) | 0.23 (0.17–0.33) | 20 (13–30) | 0.89 (0.86–0.91) |
| < 100 | 15 | 591 | 396 | 0.78 (0.74–0.82) | 0.88 (0.79–0.94) | 6.7 (3.7–12.2) | 0.24 (0.20–0.30) | 27 (13–58) | 0.85 (0.82–0.88) |