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Outcome
|
Adjusted OR/β-coefficient (95% CI)
|
p value
|
|---|
|
Hyperchloremiaa
|
|
Diluent group (Saline)
|
2.09 (1.31–3.34)
|
0.002
|
|
Chloride at ICU admission, mmol/L
|
1.15 (1.08–1.22)
|
< 0.001
|
|
Age, year
|
1.0 (0.98–1.02)
|
0.976
|
|
Weight, kg
|
1.0 (0.99–1.02)
|
0.632
|
|
APACHE III score
|
1.02 (1.01–1.03)
|
< 0.001
|
|
Time from hospitalization to ICU, days
|
1.0 (0.99–1.01)
|
0.88
|
|
Patient category
|
|
Planned surgical
|
Reference
| |
|
Unplanned surgical
|
2.37 (1.16–4.83)
|
0.018
|
|
Medical from ward
|
2.23 (1.02–4.88)
|
0.044
|
|
Medical from ED
|
1.88 (0.86–4.09)
|
0.112
|
|
Blood glucose SDb
|
|
Diluent group (Saline)
|
0.4 (− 1.37 to 2.18)
|
0.655
|
|
Blood glucose at ICU admission, mg/dL
|
0.03 (0–0.07)
|
0.089
|
|
Age, year
|
0.08 (0.02–0.15)
|
0.01
|
|
Weight, kg
|
− 0.07 (− 0.14 to − 0.01)
|
0.029
|
|
APACHE III score
|
0.06 (0.02–0.98)
|
0.006
|
|
Time from hospitalization to ICU, days
|
0.02 (− 0.04 to 0.09)
|
0.490
|
|
Patient category
|
|
Planned surgical
|
Reference
| |
|
Unplanned surgical
|
0.31 (− 1.96 to 2.58)
|
0.788
|
|
Medical from ward
|
5.72 (2.91–8.52)
|
< 0.001
|
|
Medical from ED
|
0.87 (− 1.71 to 3.44)
|
0.51
|
|
AKI diagnosisc
| | |
|
Diluent group (Saline)
|
1.11 (0.79–1.56)
|
0.542
|
|
Creatinine at ICU admission, mg/dL
|
2.57 (1.31–5.05)
|
0.006
|
|
Chloride at ICU admission, mmol/L
|
1.0 (0.96–1.03)
|
0.816
|
|
Age, year
|
0.99 (0.98–1.01)
|
0.347
|
|
Weight, kg
|
1.01 (0.99–1.02)
|
0.273
|
|
APACHE III score
|
1.02 (1.01–1.03)
|
< 0.001
|
|
Time from hospitalization to ICU, days
|
0.99 (0.98–1.0)
|
0.034
|
|
Patient category
|
|
Planned surgical
|
Reference
| |
|
Unplanned surgical
|
0.43 (0.27–0.68)
|
< 0.001
|
|
Medical from ward
|
0.94 (0.51–1.75)
|
0.854
|
|
Medical from ED
|
1.31 (0.72–2.38)
|
0.372
|
- aPatients with baseline chloride ≥ 110 mmol/L were excluded (311 patients)
- bPatients with blood glucose < 70 mg/dL or ≥ 180 mg/dL were excluded (200 patients)
- cPatients who received a diagnosis of AKI at ICU admission were excluded (205 patients)
- AKI acute kidney injury, APACHE III Acute Physiology and Chronic Health Evaluation III, ED emergency department, ICU intensive care unit, OR odds ratio, SD standard deviation
