Table 2 Levels of the biomarkers of endothelial damage and cytokines in the three groups evaluated in this investigation
From: Endothelial glycocalyx shedding in the acute respiratory distress syndrome after flu syndrome
| Biomarkers, median (IQR) | Flu syndrome | |||
|---|---|---|---|---|
|
With ARDS N = 30 |
Without ARDS N = 36 |
Control N = 35 | p value | |
| Hyaluronan (ng/ml) | 31 (12–56) | 5 (3–10) | 5 (2–8) | < 0.0001* |
| Thrombomodulin (pg/ml) | 1411 (878–2237) | 1390 (21–1746) | 219 (21–601) | < 0.0001‡ |
| Syndecan-1 (ng/ml) | 28 (24–57) | 24 (24–25) | 24 (17–41) | 0.011§ |
| TNF-α (pg/ml) | 15 (15–51) | 15 (15–43) | 23 (5–110) | 0.850 |
| IL-6 (pg/ml) | 39 (12–129) | 33 (6–83) | 16 (6–41) | 0.081 |
| IL-1β (pg/ml) | 4 (0.4–32) | 0.4 (0.4–45) | 4 (0.4–10) | 0.788 |
| Positive RT-PCR or IgM for influenza A | ||||
|
With ARDS N = 17 |
Without ARDS N = 13 |
Control N = 35 | ||
| Hyaluronan (ng/ml) | 34 (16–62) | 8 (4–15) | 5 (2–8) | 0.001** |
| Thrombomodulin (pg/ml) | 1374 (923–1980) | 1339 (575–1888) | 219 (21–601) | < 0.0001‡‡ |
| Syndecan-1 (ng/ml) | 24 (24–41) | 24 (19–70) | 24 (17–41) | 0.427 |
| TNF-α (pg/ml) | 15(15–30) | 15 (12–26) | 23 (5–109) | 0.745 |
| IL-6 (pg/ml) | 37 (1283) | 52 (6–98) | 16(6–41) | 0.255 |
| IL-1β (pg/ml) | 4 (0.4–33) | 4 (0.4–47) | 4(0.4–10) | 0.957 |